Drug search by name

Imipenem, Cilastatin, and Relebactam and Hemodialysis

Result of checking the interaction of drug Imipenem, Cilastatin, and Relebactam and disease Hemodialysis for safety when used together.

Check result:

Imipenem, Cilastatin, and Relebactam <> Hemodialysis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

In patients undergoing hemodialysis, carbapenems are recommended only if the benefit outweighs the potential risk of seizures. Carbapenems are removed by hemodialysis and should be administered after dialysis to avoid premature removal of the drug. There is not enough information regarding the use of some carbapenems such as meropenem for injection in patients on dialysis.

References:

Meyer MM, Munar MY, Kohlhepp SJ, Bryant RE "Meropenem pharmacokinetics in a patient with multiorgan failure from meningococcemia undergoing continuous venovenous hemodiafiltration." Am J Kidney Dis 33 (1999): 790-5
"Product Information. Primaxin (imipenem)." Merck & Co, Inc, West Point, PA.
Giles LJ, Jennings AC, Thomson AH, Creed G, Beale RJ, McLuckie A "Pharmacokinetics of meropenem in intensive care unit patients receiving continuous veno-venous hemofiltration or hemodiafiltration." Crit Care Med 28 (2000): 632-7
"Product Information. Merrem (meropenem)." Zeneca Pharmaceuticals, Wilmington, DE.
Krueger WA, Schroeder TH, Hutchison M, Hoffmann E, Dieterich HJ, Heininger A, Erley C, Wehrle A, Unertl K "Pharmacokinetics of meropenem in critically ill patients with acute renal failure treated by continuous hemodiafiltration." Antimicrob Agents Chemother 42 (1998): 2421-4
Thalhammer F, Schenk P, Burgmann H, ElMenyawi I, Hollenstein UM, Rosenkranz AR, SunderPlassmann G, Breyer S, Ratheiser K "Single-dose pharmacokinetics of meropenem during continuous venovenous hemofiltration." Antimicrob Agents Chemother 42 (1998): 2417-20
Hashimoto S, Honda M, Yamaguchi M, Sekimoto M, Tanaka Y "Pharmacokinetics of imipenem and cilastatin during continuous venovenous hemodialysis in patients who are critically ill." Asaio J 43 (1997): 84-8

Imipenem, Cilastatin, and Relebactam

Generic Name: cilastatin / imipenem / relebactam

Brand Name:

Synonyms: n.a.

What is Imipenem, Cilastatin, and Relebactam?