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Amantadine Extended-Release Capsules and Renal dysfunction

Result of checking the interaction of drug Amantadine Extended-Release Capsules and disease Renal dysfunction for safety when used together.

Check result:

Amantadine Extended-Release Capsules <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Amantadine is primarily eliminated by the kidney. Patients with renal impairment may be at greater risk for adverse effects from amantadine due to decreased drug clearance. Therapy with amantadine should be administered cautiously in patients with renal impairment. Dosage adjustments are recommended for patients with moderate to severe renal dysfunction.

References:

Wu MJ, Ing TS, Soung LS, Daugirdas JT, Hano JE, Gandhi VC "Amantadine hydrochloride pharmacokinetics in patients with impaired renal function." Clin Nephrol 17 (1982): 19-23
Horadam VW, Sharp JG, Smilack JD, et al "Pharmacokinetics of amantadine hydrochloride in subjects with normal and impaired renal function." Ann Intern Med 94 (1981): 454-8
Borison RL "Amantadine-induced psychosis in a geriatric patient with renal disease." Am J Psychiatry 136 (1979): 111-2
Ing TS, Daugirdas JT, Soung LS, et al "Toxic effects of amantadine in patients with renal failure." Can Med Assoc J 120 (1979): 695-8
"Product Information. Symmetrel (amantadine)." DuPont Pharmaceuticals, Wilmington, DE.
Armbruster KF, Rahn AC, Ing TS, Halper IS, Oyama JH, Klawans HL "Amantadine toxicity in a patient with renal insufficiency." Nephron 13 (1974): 183-6

Amantadine Extended-Release Capsules

Generic Name: amantadine

Brand Name: Gocovri, Osmolex ER, Symmetrel

Synonyms: Amantadine

What is Amantadine Extended-Release Capsules?