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Iron dextran and Hypersensitivity reactions

Result of checking the interaction of drug Iron dextran and disease Hypersensitivity reactions for safety when used together.

Check result:

Iron dextran <> Hypersensitivity reactions

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hypersensitivity reactions, including anaphylaxis, have occurred after uneventful test doses as well as therapeutic doses of iron dextran injection, usually within the first several minutes of administration. Iron dextran should be administered cautiously in patients with a history of significant allergies and/or asthma. Epinephrine should be immediately available in the event of acute hypersensitivity reactions.

References:

Amitai A, Acker M "Adverse effects of intramuscular iron injection." Acta Haematol 68 (1982): 341-2
Jacobs J "Death due to iron parenterally." South Med J 62 (1969): p216assim
Altman LC, Petersen PE "Successful prevention of an anaphylactoid reaction to iron dextran." Ann Intern Med 109 (1988): 346-7
Berliner S, Shoenfeld Y, Livni E, Pinkhas J "Allergic purpura following intravenous administration of iron dextran." Acta Haematol 62 (1979): 178
Zipf RE Jr "Fatal anaphylaxis after intravenous iron dextran." J Forensic Sci 20 (1975): 326-33
Becker CE, MacGregor RR, Walker KS, Jandl JH "Fatal anaphylaxis after intramuscular iron-dextran." Ann Intern Med 65 (1966): 745-8
Bielory L "Serum sickness from iron-dextran administration." Acta Haematol 83 (1990): 166-8
Hart GD, Soots M "An anaphylactic reaction complicating total dose infusion therapy of iron deficiency." Appl Ther 11 (1969): 645-6
Kumpf VJ, Holland EG "Parenteral iron dextran therapy." DICP 24 (1990): 162-6
"Product Information. INFeD (iron dextran)." Schein Pharmaceuticals Inc, Florham Park, NJ.

Iron dextran

Generic Name: iron dextran

Brand Name: DexFerrum, Infed

Synonyms: Iron Dextran Complex

What is Iron dextran?