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Isotretinoin Capsules and Elevated serum triglycerides

Generic Name: isotretinoin
Dosage Forms: capsule, liquid filled
Other Brand Names: Absorica , Amnesteem , Claravis , Myorisan , Sotret , Zenatane , Accutane

Result of checking the interaction of drug Isotretinoin Capsules and disease Elevated serum triglycerides for safety when used together.

Check result:

Isotretinoin Capsules <> Elevated serum triglycerides

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of retinoids is associated with elevations in serum triglycerides and cholesterol, and decreases in HDL. In addition to cardiovascular risks, elevation of serum triglycerides to greater than 800 mg/dL has been associated with fatal fulminant pancreatitis. Patients at increased risk for developing hypertriglyceridemia during retinoid therapy include those with diabetes mellitus, obesity, high alcohol consumption, or a family history of these conditions. Blood lipid determinations should be performed prior to initiation of therapy and at 1- to 2- week intervals until the lipid response to the drug is established (usually 4 to 8 weeks). Patients with preexisting hyperlipidemia may require closer monitoring during retinoid therapy, and adjustments made accordingly in their lipid-lowering regimen.

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