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Amerge and Liver disease

Generic Name: naratriptan
Dosage Forms: tablet, film coated
Other Brand Names: Amerge

Result of checking the interaction of drug Amerge and disease Liver disease for safety when used together.

Check result:

Amerge <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The manufacturer considers the use of naratriptan to be contraindicated in patients with severe hepatic impairment (Child-Pugh grade C). Naratriptan is partially metabolized by the liver. In patients with moderate hepatic impairment (Child-Pugh grade A or B), the clearance of naratriptan has been shown to decrease by 30% compared to healthy controls, resulting in an approximately 40% increase in the mean half-life. A lower initial dosage should be considered in patients with mild or moderate hepatic impairment, and the maximum dosage should not exceed 2.5 mg per 24-hour period. There are no data concerning the use of naratriptan in patients with severe hepatic impairment, thus it is not recommended.

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