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Amerge and Renal dysfunction

Generic Name: naratriptan
Dosage Forms: tablet, film coated
Other Brand Names: Amerge

Result of checking the interaction of drug Amerge and disease Renal dysfunction for safety when used together.

Check result:

Amerge <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The manufacturer considers the use of naratriptan to be contraindicated in patients with severe renal impairment (CrCl < 15 mL/min). Naratriptan is primarily eliminated by the kidney, approximately 50% as parent drug and 30% as metabolites. In patients with moderate renal impairment (CrCl = 18 to 39 mL/min), the clearance of naratriptan has been shown to decrease by 50% compared to healthy controls, resulting in an approximately 83% increase in the mean half-life. A lower initial dosage should be considered in patients with mild or moderate renal impairment, and the maximum dosage should not exceed 2.5 mg per 24-hour period. There are no data concerning the use of naratriptan in patients with severe renal impairment, thus it is not recommended.

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