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Kemadrin and Liver disease
Result of checking the interaction of drug Kemadrin and disease Liver disease for safety when used together.
Check result:
Kemadrin <> Liver disease
Relevance: 23.07.2019
Reviewer: Shkutko P.M., M.D., in
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:The clearance of anticholinergics may be decreased in the presence of liver disease. Therapy with anticholinergics should be administered cautiously and may require less frequent dosing to avoid adverse effects in patients with liver disease.
References:
- Glazko AJ, Dill WA, Young RM, Smith TC, Ogilvie RI "Metabolic disposition of diphenhydramine." Clin Pharmacol Ther 16 (1974): 1066-76
- Meredith CG, Christian CD Jr, Johnson RF, Madhavan SV, Schenker S "Diphenhydramine disposition in chronic liver disease." Clin Pharmacol Ther 35 (1984): 474-9
- "Product Information. Benadryl (diphenhydramine)." Parke-Davis, Morris Plains, NJ.
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