Drug search by name

Lesinurad and Allopurinol and Liver disease

Result of checking the interaction of drug Lesinurad and Allopurinol and disease Liver disease for safety when used together.

Check result:

Lesinurad and Allopurinol <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of allopurinol has infrequently been associated with asymptomatic elevations of serum transaminase and alkaline phosphatase levels. Isolated cases of cholestatic jaundice, hepatic necrosis, granulomatous hepatitis, and hepatomegaly have also been reported. Therapy with allopurinol should be administered cautiously in patients with liver disease. Periodic monitoring of liver function tests is recommended in these patients during the early stages of therapy.

References:

Al-Kawas FH, Seeff LB, Berendson RA, Zimmerman HJ, Ishak KG "Allopurinol hepatotoxicity." Ann Intern Med 95 (1981): 588-90
"Product Information. Zyloprim capsules (allopurinol)." Glaxo Wellcome, Research Triangle Park, NC.
Ohsawa T, Ohtsubo M "Hepatitis associated with allopurinol." Drug Intell Clin Pharm 19 (1985): 431-3
Raper R, Ibels L, Lauer C, Barnes P, Lunzer M "Fulminant hepatic failure due to allopurinol." Aust N Z J Med 14 (1984): 63-5

Lesinurad and Allopurinol

Generic Name: allopurinol / lesinurad

Brand Name: Duzallo

Synonyms: Allopurinol and lesinurad

What is Lesinurad and Allopurinol?