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Leukine (Sargramostim Powder for Injection) and Respiratory symptoms

Result of checking the interaction of drug Leukine (Sargramostim Powder for Injection) and disease Respiratory symptoms for safety when used together.

Check result:

Leukine (Sargramostim Powder for Injection) <> Respiratory symptoms

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Sargramostim may cause an influx of granulocytes in the pulmonary circulation. Dyspnea has been reported occasionally during or after treatment. Therapy with sargramostim should be administered cautiously in patients with lung disease or hypoxia. Respiratory status should be monitored during and immediately after therapy, and the infusion rate reduced by half if dyspnea occurs during IV administration. In patients who do not respond to the rate reduction or experience a worsening of symptoms, the infusion should be discontinued. For subsequent infusions, the standard rate schedule may be resumed (with careful monitoring), since respiratory symptoms often do not recur within the same treatment cycle.

References:

Rosenfeld CS, Sulecki M, Evans C, Shadduck RK "Comparison of intravenous versus subcutaneous recombinant human GM-CSF in patients with primary myelodysplasia." Exp Hematol 19 (1991): 273-7
"Product Information. Prokine (sargramostim)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Mehregan DR, Fransway AF, Edmonson JH, Leiferman KM "Cutaneous reactions to granulocyte-monocyte colony-stimulating factor." Arch Dermatol 128 (1992): 1055-9
Nemunaitis J, Buckner CD, Appelbaum FR, Higano CS, Mori M, Bianco J, Epstein C, Lipani J, Hansen J, Storb R, et al "Phase I/II trial of recombinant human granulocyte-macrophage colony- stimulating factor following allogeneic bone marrow transplantation." Blood 77 (1991): 2065-71
"Product Information. Leukine (sargramostim)." Immunex Corporation, Seattle, WA.

Leukine (Sargramostim Powder for Injection)

Generic Name: sargramostim

Brand Name: Leukine

Synonyms: Leukine

What is Leukine (Sargramostim Powder for Injection)?