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Lidocaine and Hydrocortisone Rectal Cream and Hepatic dysfunction

Result of checking the interaction of drug Lidocaine and Hydrocortisone Rectal Cream and disease Hepatic dysfunction for safety when used together.

Check result:

Lidocaine and Hydrocortisone Rectal Cream <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Lidocaine topical is absorbed through intact skin and mucosal membranes. Prolonged exposure, large doses, and/or application to compromised skin or mucosa can result in elevated plasma concentrations of lidocaine. Lidocaine is rapidly and extensively metabolized by the liver. Less than 10% is eliminated unchanged in the urine. Several inactive and two active forms (MEGX and GX) have been identified. MEGX and GX exhibit antiarrhythmic and convulsant properties. The pharmacokinetic disposition of lidocaine is altered by changes in hepatic function, including hepatic blood flow. Therapy with lidocaine topical should be administered cautiously and dosing modified for patients with compromised hepatic function.

Lidocaine and Hydrocortisone Rectal Cream

Generic Name: hydrocortisone / lidocaine topical

Brand Name: Ana-Lex, LidaMantle HC, AnaMantle HC, Lidazone HC, AnaMantle HC Forte, Senatec HC, RectaGel HC, Peranex HC, LidaMantle HC Relief, Xyralid LP, Xyralid, BP Ana-Lex HC, LidoCort

Synonyms: Hydrocortisone and lidocaine (topical/rectal), Lidocaine and Hydrocortisone Cream

What is Lidocaine and Hydrocortisone Rectal Cream?