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Lynparza (Olaparib Capsules) and Hepatic impairment

Result of checking the interaction of drug Lynparza (Olaparib Capsules) and disease Hepatic impairment for safety when used together.

Check result:

Lynparza (Olaparib Capsules) <> Hepatic impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Olaparib primarily undergoes hepatic metabolism via CYP450 3A4 and CYP450 3A5; the majority of metabolism is through oxidation with some metabolites undergoing subsequent glucuronide or sulfate conjugation. No dose adjustment is needed in patients with mild hepatic impairment. It is recommended to use caution when using olaparib in patients with moderate or severe hepatic impairment as there are no data available. Close monitoring is recommended.

Lynparza (Olaparib Capsules)

Generic Name: olaparib

Brand Name: Lynparza

Synonyms: Lynparza

What is Lynparza (Olaparib Capsules)?