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Macrobid and Renal dysfunction

Result of checking the interaction of drug Macrobid and disease Renal dysfunction for safety when used together.

Check result:

Macrobid <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of nitrofurantoin is contraindicated in patients with anuria, oliguria, or significant renal impairment (CrCl < 60 mL/min). Urinary concentration of the drug is likely to be inadequate in these patients, increasing the risk of therapeutic failure. Since nitrofurantoin is eliminated by the kidney, risk of toxicity may also be increased.

References:

"Product Information. Macrobid (nitrofurantoin)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.
Sachs J, Geer T, Noell P, Kunin CM "Effect of renal function on urinary recovery of orally administered nitrofurantoin." N Engl J Med 278 (1967): 1032-5
Hoener B, Patterson SE "Nitrofurantoin disposition." Clin Pharmacol Ther 29 (1981): 808-16
Goff JB, Schlegel JU, O'Dell RM "Urinary excretion of nalidixic acid, sulfamethizole and nitrofurantoin in patients with reduced renal function." J Urol 99 (1968): 371-5
Schirmeister J, Stefani F, Willmann H, Hallauer W "Renal handling of nitrofurantoin in man." Chemotherapy 5 (1965): 223-6
Glascock HW, Jr "Nitrofurantoin in renal failure." Ann Intern Med 69 (1968): 1077

Macrobid

Generic Name: nitrofurantoin

Brand Name: Furadantin, Macrobid, Macrodantin, Nitro Macro

Synonyms: n.a.

What is Macrobid?