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Mebendazole and Liver disease

Result of checking the interaction of drug Mebendazole and disease Liver disease for safety when used together.

Check result:

Mebendazole <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Although mebendazole is poorly absorbed from the gastrointestinal tract (only 2% to 10% of a dose is absorbed systemically), absorbed drug is primarily metabolized by the liver. Therapy with mebendazole should be administered cautiously in patients with liver disease. Liver function tests should be monitored during extended use or high-dose therapy, since elevation of serum transaminases (AST, ALT) and GGT, as well as rare cases of hepatitis, have been reported during prolonged therapy and at dosages substantially above those normally recommended.

References:

Bekhti A, Pirotte J "Hepatotoxicity of mebendazole: relationship with serum concentrations of the drug." Gastroenterol Clin Biol 11 (1987): 701-3
"Product Information. Vermox (mebendazole)." Janssen Pharmaceutica, Titusville, NJ.
Witassek F, Bircher "Chemotherapy of larval echinococcosis with mebendazole: microsomal liver function and cholestasis as determinants of plasma drug level." Eur J Clin Pharmacol 25 (1983): 85-90

Mebendazole

Generic Name: mebendazole

Brand Name: Emverm, Vermox

Synonyms: n.a.

What is Mebendazole?