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Meperidine and Promethazine and Seizure disorders

Result of checking the interaction of drug Meperidine and Promethazine and disease Seizure disorders for safety when used together.

Check result:

Meperidine and Promethazine <> Seizure disorders

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Narcotic (opioid) analgesic agents may exacerbate seizures in patients with seizure disorders and, at higher dosages, have been reported to induce seizures in patients without previous history of seizures. The proconvulsant activity may be the greatest with meperidine, the active metabolite of which is thought to be responsible. Therapy with opioids should be administered cautiously in patients with or predisposed to seizures.

References:

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Meperidine and Promethazine

Generic Name: meperidine / promethazine

Brand Name:

Synonyms: n.a.

What is Meperidine and Promethazine?

Another drug Delete

Meperidine and Promethazine <> Seizure disorders

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

Consumer:

Phenothiazines can lower the seizure threshold and induce seizures, particularly when dosages are high or increased rapidly and during the initiation of therapy. Of the phenothiazines used in the treatment of psychosis, chlorpromazine appears to have the greatest epileptogenic potential, while fluphenazine and thioridazine have the least. Therapy with phenothiazines should be administered cautiously in patients with a history of seizures or other factors predisposing to seizures such as abnormal EEG, preexisting CNS pathology, or head trauma. Adequate anticonvulsant therapy should be maintained during administration of phenothiazines.

References:

DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM "Pharmacotherapy: A Pathophysiologic Approach 4th" Stamford, CT: Appleton & Lange (1999):
"Product Information. Tacaryl (methdilazine)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
"Product Information. Serentil (mesoridazine)" Boehringer-Ingelheim, Ridgefield, CT.
"Product Information. Vesprin (triflupromazine)" Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Mellaril (thioridazine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
"Product Information. Moban (molindone)." Gate Pharmaceuticals, Sellersville, PA.
"Product Information. Stelazine (trifluoperazine)" SmithKline Beecham, Philadelphia, PA.
"Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Sparine (promazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Prolixin (fluphenazine)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Torecan (thiethylperazine)" Roxane Laboratories Inc, Columbus, OH.
"Product Information. Compazine (prochlorperazine)." SmithKline Beecham, Philadelphia, PA.
Markowitz J, Brown R "Seizures with neuroleptics and antidepressants." Gen Hosp Psychiatry 9 (1987): 135-41
"Product Information. Trilafon (perphenazine)" Schering Corporation, Kenilworth, NJ.
"Product Information. Temaril (trimeprazine)" Allergan Inc, Irvine, CA.
Waterhouse RG "Epileptiform convulsions in children following premedication with Pamergan SP100." Br J Anaesth 39 (1967): 268-70
"Product Information. Thorazine (chlorpromazine)." SmithKline Beecham, Philadelphia, PA.
"Product Information. Orap Tablets (pimozide)." Gate Pharmaceuticals, Sellersville, PA.