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Methylnaltrexone bromide and Intestinal obstruction

Result of checking the interaction of drug Methylnaltrexone bromide and disease Intestinal obstruction for safety when used together.

Check result:

Methylnaltrexone bromide <> Intestinal obstruction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Peripheral opioid receptor antagonists are contraindicated in patients with known or suspected gastrointestinal obstruction, and in patients at increased risk of recurrent obstruction, due to the potential for gastrointestinal perforation. Cases of gastrointestinal perforation have been reported in patients with opioid-induced constipation and advanced illness with conditions that may be associated with localized or diffuse reduction of structure integrity in the wall of the GI tract such as peptic ulcer, diverticular disease, Crohn's disease, infiltrative GI tract malignancies or peritoneal metastases. It is recommended to monitor for the development of severe, persistent, or worsening abdominal pain and to discontinue treatment in patients who develop symptoms. The overall risk- benefit profile should be carefully evaluated before using these agents in patients with these conditions.

Methylnaltrexone bromide

Generic Name: methylnaltrexone

Brand Name: Relistor

Synonyms: Methylnaltrexone (oral/injection), Methylnaltrexone

What is Methylnaltrexone bromide?