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Milrinone Dextrose and Liver disease

Result of checking the interaction of drug Milrinone Dextrose and disease Liver disease for safety when used together.

Check result:

Milrinone Dextrose <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of inamrinone (former amrinone) has been associated with hepatotoxicity, manifested as marked alterations in liver function tests and clinical symptoms suggestive of idiosyncratic hypersensitivity. This especially after long-term use. Therapy with inamrinone should be administered cautiously if at all in patients with liver disease and discontinuation of the drug may be required if symptoms worsen. Monitoring of liver functions tests prior to and during therapy is recommended.

References:

Silverman B, Merrill A, Gerber L "Clinical effects and side effects of amrinone. A study of 24 patients with chronic congestive heart failure." Arch Intern Med 145 (1985): 825-9
"Product Information. Inocor (inamrinone)." Sanofi Winthrop Pharmaceuticals, New York, NY.
Bottorff MB, Rutledge DR, Pieper JA "Evaluation of intravenous amrinone: the first of a new class of positive inotropic agents with vasodilator properties." Pharmacotherapy 5 (1985): 227-37
Dunkman WB, Wilen MM, Franciosa JA "Adverse effects of long-term amrinone administration in congestive heart failure." Am Heart J 105 (1983): 861-3
Wilsmhurst PT, Webb-Peploe MM "Side effects of amrinone therapy." Br Heart J 49 (1983): 447-51
Mancini D, LeJemtel T, Sonnenblick E "Intravenous use of amrinone for the treatment of the failing heart." Am J Cardiol 56 (1985): b8-15
Gilman ME, Margolis SC "Amrinone-induced hepatotoxicity." Clin Pharm 3 (1984): 422-4
Massie B, Bourassa M, DiBianco R, Hess M, Konstam M, Likoff M, Packer M "Long-term oral administration of amrinone for congestive heart failure: lack of efficacy in a multicenter controlled trial." Circulation 71 (1985): 963-71
DiBianco R, Shabetai R, Silverman BD, Leier CV, Benotti JR "Oral amrinone for the treatment of chronic congestive heart failure: results of a multicenter randomized double-blind and placebo- controlled withdrawal study." J Am Coll Cardiol 4 (1984): 855-66

Milrinone Dextrose

Generic Name: milrinone

Brand Name: Primacor, Primacor IV.

Synonyms: Milrinone

What is Milrinone Dextrose?