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Minoxidil (Systemic) and Fluid retention/congestive heart failure

Result of checking the interaction of drug Minoxidil (Systemic) and disease Fluid retention/congestive heart failure for safety when used together.

Check result:

Minoxidil (Systemic) <> Fluid retention/congestive heart failure

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Minoxidil tablets must usually be administered with a diuretic to prevent fluid retention and possible congestive heart failure; a high ceiling (loop) diuretic is almost always required. Body weight should be monitored closely. If minoxidil is used without a diuretic, retention of salt and corresponding volumes of water can occur within a few days, leading to increased plasma and interstitial fluid volume and local or generalized edema. Caution and close monitoring is advised in patients with preexisting congestive heart failure. Pericardial effusion, occasionally with tamponade, has been also observed in about 3% of treated patients not on dialysis, especially those with inadequate or compromised renal function. In some cases, the pericardial effusion was associated with a congestive heart failure, or marked fluid retention. Rarely, refractory fluid retention may require discontinuation of minoxidil. Provided that the patient is under close medical supervision, it may be possible to resolve refractory salt retention by discontinuing minoxidil for 1 or 2 days and then resuming treatment in conjunction with vigorous diuretic therapy.

Minoxidil (Systemic)

Generic Name: minoxidil

Brand Name: Loniten

Synonyms: Minoxidil

What is Minoxidil (Systemic)?