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Ancobon and Myelosuppression

Result of checking the interaction of drug Ancobon and disease Myelosuppression for safety when used together.

Check result:

Ancobon <> Myelosuppression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Flucytosine may frequently cause bone marrow toxicity, which can be irreversible and fatal in immunosuppressed patients. Flucytosine should be used with extreme caution in patients with preexisting bone marrow suppression. Frequent blood counts are recommended.

References:

Wise GJ, Goldberg P, Kozinn PJ, Nawabi IU "Agranulocytosis associated with flucytosine for urinary candidiasis." Urology 8 (1976): 490-1
"Product Information. Ancobon (flucytosine)." Roche Laboratories, Nutley, NJ.
Harder EJ, Hermans PE "Treatment of fungal infections with flucytosine." Arch Intern Med 135 (1975): 231-7
Bennett JE, Dismukes WE, Duma RJ, et al "A comparison of amphotericin B alone and combined with flucytosine in the treatment of cryptococcal meningitis." N Engl J Med 301 (1979): 126-31
Kauffman CA, Frame PT "Bone marrow toxicity associated with 5-fluorocytosine therapy." Antimicrob Agents Chemother 11 (1977): 244-7
Record CO, Skinner JM, Sleight P, Speller DC "Candida endocarditis treated with 5-fluorocytosine." Br Med J 01/30/71 (1971): 262-4
Stamm AM, Diasio RB, Dismukes WE, et al "Toxicity of amphotericin B plus flucytosine in 194 patients with cryptococcal meningitis." Am J Med 83 (1987): 236-42

Ancobon

Generic Name: flucytosine

Brand Name: Ancobon

Synonyms: n.a.

What is Ancobon?