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NegGram and Liver disease

Result of checking the interaction of drug NegGram and disease Liver disease for safety when used together.

Check result:

NegGram <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Nalidixic acid is primarily metabolized by the liver and may accumulate in patients with impaired hepatic function. Therapy with nalidixic acid should be administered cautiously in patients with liver disease.

References:

"Product Information. NegGram (nalidixic acid)." Sanofi Winthrop Pharmaceuticals, New York, NY.
Vree TB, Wijnands WJ, Baars AM, Hekster YA "Pharmacokinetics of nalidixic acid in man: hydroxylation and glucoronidation." Pharm Weekbl Sci 10 (1988): 193-9
Gleckman R, Alvarez S, Joubert DW, Matthews SJ "Drug therapy reviews: nalidixic acid." Am J Hosp Pharm 36 (1979): 1071-6
Ferry N, Cuisinaud G, Pozet N, Zech PY, Sassard J "Nalidixic acid kinetics after single and repeated oral doses." Clin Pharmacol Ther 29 (1981): 695-8
Mannisto PT "Pharmacokinetics of nalidixinic acid and oxolinic acid in healthy women." Clin Pharmacol Ther 19 (1975): 37-46

NegGram

Generic Name: nalidixic acid

Brand Name:

Synonyms: n.a.

What is NegGram?