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Neutrexin and Bone marrow suppression

Generic Name: trimetrexate
Dosage Forms: for Injection
Other Brand Names:

Result of checking the interaction of drug Neutrexin and disease Bone marrow suppression for safety when used together.

Check result:

Neutrexin <> Bone marrow suppression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of trimetrexate is associated with severe and potentially life-threatening bone marrow suppression. Concomitant use with leucovorin significantly diminishes but does not eliminate this risk. Therapy with trimetrexate should be administered cautiously in patients with preexisting blood dyscrasias and in patients receiving other myelotoxic drugs. Close clinical monitoring of hematopoietic function is recommended during therapy, and patients should be instructed to immediately report any signs or symptoms suggestive of hematologic toxicity such as fever, sore throat, local infection, bleeding, pallor, dizziness, or jaundice. The dosages of trimetrexate and leucovorin should be adjusted for hematologic toxicity in accordance with the product package labeling.

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