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Neutrexin and Renal/liver disease

Result of checking the interaction of drug Neutrexin and disease Renal/liver disease for safety when used together.

Check result:

Neutrexin <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Trimetrexate undergoes both renal and hepatic elimination. Therapy with trimetrexate should be administered cautiously in patients with renal and/or hepatic impairment, since they may be at increased risk for potentially life-threatening hematologic and gastrointestinal toxicities associated with the drug. In addition, trimetrexate may be nephro- and hepatotoxic. Elevations in serum creatinine and liver function tests occur in approximately 1% and up to 14%, respectively, of patients treated with trimetrexate and leucovorin. The manufacturer recommends blood tests at least twice a week during therapy to assess hematologic, renal, and hepatic function. Interruption of therapy is advised if serum creatinine level exceeds 2.5 mg/dL or if serum transaminase or alkaline phosphatase levels increase to > 5 times the upper limits of normal and these elevations are thought to be secondary to trimetrexate.

References:

Fanucchi MP, Walsh TD, Fleisher M, Lokos G, Williams L, Cassidy C, Vidal P, Chou TC, Niedzwiecki D, Young CW "Phase I and clinical pharmacology study of trimetrexate administered weekly for three weeks." Cancer Res 47 (1987): 3303-8
"Product Information. Neutrexin (trimetrexate)." US Bioscience, West Conshohocken, PA.
Reece PA, Morris RG, Bishop JF, Olver IN, Raghavan D "Pharmacokinetics of trimetrexate administered by five-day continuous infusion to patients with advanced cancer." Cancer Res 47 (1987): 2996-9
Lin JT, Cashmore AR, Baker M, Dreyer RN, Ernstoff M, Marsh JC, Bertino JR, Whitfield LR, Delap R, Grillo-Lopez A "Phase I studies with trimetrexate: clinical pharmacology, analytical methodology, and pharmacokinetics." Cancer Res 47 (1987): 609-16

Neutrexin

Generic Name: trimetrexate

Brand Name:

Synonyms: n.a.

What is Neutrexin?