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Nivolumab Intravenous and Renal dysfunction

Result of checking the interaction of drug Nivolumab Intravenous and disease Renal dysfunction for safety when used together.

Check result:

Nivolumab Intravenous <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Nivolumab can cause immune-mediated nephritis. Monitor patients for elevated serum creatinine prior to and periodically during treatment. It is recommended to administer corticosteroids at a dose of 1 to 2 mg/kg/day prednisone equivalents followed by corticosteroid taper for life-threatening increased serum creatinine. Administer corticosteroids at a dose of 0.5 to 1 mg/kg/day prednisone equivalents for moderate or severe increased serum creatinine, if worsening or no improvement occurs, increase dose of corticosteroids to 1 to 2 mg/kg/day prednisone equivalents. Withhold nivolumab for moderate or severe increased serum creatinine. Permanently discontinue nivolumab for life-threatening increased serum creatinine. If appropriate modify the dose according to manufacturer recommendations when nivolumab is administered in combination with ipilimumab, and if nivolumab is withheld, ipilimumab should also be withheld. Care should be taken when using nivolumab in patients with renal dysfunction.

Nivolumab Intravenous

Generic Name: nivolumab

Brand Name: Opdivo

Synonyms: Nivolumab

What is Nivolumab Intravenous?