Drug search by name

Northera and Ischemic heart disease/arrhythmias/CHF

Result of checking the interaction of drug Northera and disease Ischemic heart disease/arrhythmias/CHF for safety when used together.

Check result:

Northera <> Ischemic heart disease/arrhythmias/CHF

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Droxidopa is directly metabolized in vivo to norepinephrine via decarboxylation. As such, it may exacerbate certain cardiovascular conditions by increasing blood pressure and heart rate. Therapy with droxidopa should be considered cautiously in patients with ischemic heart disease, arrhythmias, or congestive heart failure. Additionally, droxidopa may exacerbate supine hypertension in patients with neurogenic orthostatic hypotension. Patients should be advised to elevate the head of the bed while resting or sleeping. Blood pressure should be monitored both in supine position and the head- elevated sleeping position. If hypertension persists, then droxidopa dosage should be reduced or discontinued. If hypertension is not well managed, it can increase the risk of cardiovascular events, especially stroke.

Northera

Generic Name: droxidopa

Brand Name: Northera

Synonyms: n.a.

What is Northera?