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Olanzapine and Fluoxetine and Liver disease

Result of checking the interaction of drug Olanzapine and Fluoxetine and disease Liver disease for safety when used together.

Check result:

Olanzapine and Fluoxetine <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Most neuroleptic agents are extensively metabolized by the liver. The plasma concentrations of these agents may be increased and the half-lives prolonged in patients with impaired hepatic function. Therapy with neuroleptic agents should be administered cautiously in patients with significant liver disease. Lower initial dosages and slower titration may be appropriate.

References:

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"Product Information. Moban (molindone)." Gate Pharmaceuticals, Sellersville, PA.
"Product Information. Clozaril (clozapine)." Novartis Pharmaceuticals, East Hanover, NJ.
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"Product Information. Seroquel (quetiapine)." Zeneca Pharmaceuticals, Wilmington, DE.
"Product Information. Zyprexa (olanzapine)." Lilly, Eli and Company, Indianapolis, IN.
"Product Information. Navane (thiothixene)." Roerig Division, New York, NY.
"Product Information. Loxitane C Oral Concentrate (loxapine)" Watson Laboratories Inc, Corona, CA.

Olanzapine and Fluoxetine

Generic Name: fluoxetine / olanzapine

Brand Name: Symbyax

Synonyms: Fluoxetine and olanzapine

What is Olanzapine and Fluoxetine?

Another drug Delete

Olanzapine and Fluoxetine <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

Consumer:

Selective serotonin reuptake inhibitors (SSRIs) are primarily metabolized by the liver. The plasma concentrations of SSRIs and their metabolites may be increased and the half-lives prolonged in patients with impaired hepatic function. Dosage adjustments may be necessary in accordance with the individual product package labeling.

References:

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"Product Information. Celexa (citalopram)." Forest Pharmaceuticals, St. Louis, MO.
"Product Information. Zoloft (sertraline)." Roerig Division, New York, NY.
"Product Information. Luvox (fluvoxamine)." Solvay Pharmaceuticals Inc, Marietta, GA.
"Product Information. Paxil (paroxetine)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Prozac (fluoxetine)." Dista Products Company, Indianapolis, IN.
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"Product Information. Lexapro (escitalopram)." Forest Pharmaceuticals, St. Louis, MO.
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