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Olanzapine and Fluoxetine Capsules and Renal dysfunction

Result of checking the interaction of drug Olanzapine and Fluoxetine Capsules and disease Renal dysfunction for safety when used together.

Check result:

Olanzapine and Fluoxetine Capsules <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Fluoxetine is primarily metabolized by the liver. All but one metabolites are inactive, and they are excreted by the kidney. The clearance of norfluoxetine, the active metabolite, is not dependent on renal function. Dosage adjustments are generally not deemed necessary in patients with impaired renal function, although the clinical significance of possible metabolite accumulation is unknown. Caution may be warranted when fluoxetine therapy is administered in patients with severe renal dysfunction.

References:

"Product Information. Prozac (fluoxetine)." Dista Products Company, Indianapolis, IN.
Aronoff GR, Bergstrom RF, Pottratz ST, Sloan RS, Wolen RL, Lemberger L "Fluoxetine kinetics and protein binding in normal and impaired renal function." Clin Pharmacol Ther 36 (1984): 138-44

Olanzapine and Fluoxetine Capsules

Generic Name: fluoxetine / olanzapine

Brand Name: Symbyax

Synonyms: Fluoxetine and olanzapine, Olanzapine and Fluoxetine

What is Olanzapine and Fluoxetine Capsules?