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Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets and Cirrhosis

Result of checking the interaction of drug Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets and disease Cirrhosis for safety when used together.

Check result:

Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets <> Cirrhosis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hepatic decompensation and hepatic failure, including liver transplantation or fatal outcomes, have been reported in patients with cirrhosis treated with dasabuvir. In addition, dasabuvir is associated with hepatitis B reactivation, some cases have resulted in fulminant hepatitis, hepatic failure, and death, in HCV/HBV coinfected patients. Therapy with dasabuvir should be administered cautiously in patients with cirrhosis and in HCV/HBV coinfected patients. Screening for current or prior viral hepatitis B/C infection should be performed per published guidelines before starting therapy with this agent. It is recommended to monitor patients coinfected with HCV/HBV for hepatitis flare or HBV reactivation during and after HCV therapy. Patients should have liver functions tests (ALT, AST, alkaline phosphatase, total bilirubin) at baseline and during the first 4 weeks of therapy and periodically as clinically indicated. Discontinue treatment in patients who develop evidence of hepatic decompensation, ALT elevation is accompanied by signs or symptoms of liver inflammation or if ALT levels remain persistently greater than 10 times the ULN, increasing direct bilirubin, alkaline phosphatase, or INR.

Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets

Generic Name: dasabuvir / ombitasvir / paritaprevir / ritonavir

Brand Name: Viekira XR, Viekira Pak

Synonyms: Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir

What is Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets?