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Onxol and Peripheral neuropathy

Result of checking the interaction of drug Onxol and disease Peripheral neuropathy for safety when used together.

Check result:

Onxol <> Peripheral neuropathy

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Dose-dependent peripheral neuropathy has been reported in 60% of patients during paclitaxel therapy. Severe peripheral neuropathy is rare and requires a 20% reduction in dosage of paclitaxel. Therapy with paclitaxel should be administered cautiously in patients with or predisposed to peripheral neuropathy.

References:

Rowinsky EK, Eisenhauer EA, Chaudhry V, Arbuck SG, Donehower RC "Clinical toxicities encountered with paclitaxel (Taxol)." Semin Oncol 20(4 Suppl) (1993): 1-15
Liu JM, Chen YM, Chao Y, Liu TW, Chou CM, Chen LT, Yu WL, Whangpeng J "Paclitaxel-induced severe neuropathy in patients with previous radiotherapy to the head and neck region." J Natl Cancer Inst 88 (1996): 1000-2
"Product Information. Taxol (paclitaxel)." Bristol-Myers Squibb, Princeton, NJ.

Onxol

Generic Name: paclitaxel

Brand Name: Onxol, Taxol

Synonyms: n.a.

What is Onxol?