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Orthoclone OKT 3 and Volume overload

Result of checking the interaction of drug Orthoclone OKT 3 and disease Volume overload for safety when used together.

Check result:

Orthoclone OKT 3 <> Volume overload

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of muromonab-CD3 is contraindicated in patients with fluid overload as evidences by chest X-ray or a 3% or more weight gain in the week prior to muromonab-CD3 therapy. Patients with fluid overload are at increased risk for more serious cardiopulmonary complications (respiratory arrest, failure, distress, and/or cardiovascular collapse, cardiac arrest, angina, or myocardial infarction) from muromonab-CD3-associated Cytokine Release Syndrome.

References:

Sgro C "Side-effects of a monoclonal antibody, muromonab CD3 orthoclone OKT3: bibliographic review." Toxicology 105 (1995): 23-9
"Product Information. Orthoclone OKT 3 (muromonab-CD3)." Ortho Pharmaceutical Corporation, Raritan, NJ.
Todd PA, Brogden RN "Muromonab CD3. A review of its pharmacology and therapeutic potential." Drugs 37 (1989): 871-99

Orthoclone OKT 3

Generic Name: muromonab-cd3

Brand Name:

Synonyms: Orthoclone OKT 3 (Intravenous), Orthoclone OKT3

What is Orthoclone OKT 3?