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Antizol and Hepatic/renal dysfunction

Generic Name: fomepizole
Dosage Forms: injection
Other Brand Names: Antizol

Result of checking the interaction of drug Antizol and disease Hepatic/renal dysfunction for safety when used together.

Check result:

Antizol <> Hepatic/renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The pharmacokinetic disposition of fomepizole has not been determined in patients with hepatic and/or renal impairment. Fomepizole is extensively metabolized by the liver. Following multiple dosing, fomepizole induces its own metabolism and the rate of elimination is increased. About 1% to 3.5% of fomepizole is eliminated unchanged in the urine. Therapy with fomepizole should be administered cautiously in patients with compromised hepatic and/or renal function. Fomepizole is dialyzable and the frequency of dosing should be increased to every 4 hours during hemodialysis.

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