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Penicillin G Procaine and Methemoglobinemia

Result of checking the interaction of drug Penicillin G Procaine and disease Methemoglobinemia for safety when used together.

Check result:

Penicillin G Procaine <> Methemoglobinemia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Cases of methemoglobinemia have been reported in association with local anesthetic use. Although all patients are at risk for methemoglobinemia, patients with glucose-6-phosphate dehydrogenase deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants under 6 months of age, and concurrent exposure to oxidizing agents or their metabolites are more susceptible to developing clinical manifestations of the condition. Close monitoring for symptoms and signs of methemoglobinemia is recommended on these patients. Signs of methemoglobinemia may occur immediately or may be delayed some hours after exposure, and are characterized by a cyanotic skin discoloration and/or abnormal coloration of the blood. Methemoglobin levels may continue to rise; therefore, immediate treatment is required to avert more serious central nervous system (CNS) and cardiovascular adverse effects, including seizures, coma, arrhythmias, and death. Discontinue Penicillin G Procaine and any other oxidizing agents immediately and administer supportive care.

Penicillin G Procaine

Generic Name: procaine penicillin

Brand Name: Wycillin

Synonyms: n.a.

What is Penicillin G Procaine?