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Pentam 300 and Pancreatitis

Result of checking the interaction of drug Pentam 300 and disease Pancreatitis for safety when used together.

Check result:

Pentam 300 <> Pancreatitis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Acute and potentially fatal pancreatitis has been reported with parenteral use and, rarely, oral inhalation of pentamidine. Patients with a history of or known risk factors for pancreatitis, such as alcohol abuse or hypertriglyceridemia, should be monitored closely during therapy with pentamidine. Therapy should be discontinued at the first signs or symptoms suggestive of pancreatitis (e.g., nausea, vomiting, abdominal pain, hyperamylasemia with dysglycemia, rising triglycerides, decreasing serum calcium), and preferably permanently discontinued if clinical pancreatitis develops.

References:

Tocci G, Alba L, D'Amato C, Grisetti S, Sampaolesi A, Visco GL "Pancreatitis associated with aerosolized pentamidine." Int Conf AIDS 9 (1993): 505
Wood G, Wetzig N, Hogan P, Whitby M "Survival from pentamidine induced pancreatitis and diabetes mellitus." Aust N Z J Med 21 (1991): 341-2
"Product Information. NebuPent (pentamidine)." Fujisawa, Deerfield, IL.
Sauleda J, Gea JG, Aguar MC, Aran X, Pasto M, Broquetas JM "Probable pentamidine-induced acute pancreatitis." Ann Pharmacother 28 (1994): 52-3
Schwartz MS, Cappell MS "Pentamidine-associated pancreatitis." Dig Dis Sci 34 (1989): 1617-20
Klatt EC "Pathology of pentamidine-induced pancreatitis." Arch Pathol Lab Med 116 (1992): 162-4
"Product Information. Pentam 300 (pentamidine)." Fujisawa, Deerfield, IL.

Pentam 300

Generic Name: pentamidine

Brand Name: Nebupent, Pentam 300, Pentam

Synonyms: n.a.

What is Pentam 300?