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Pentamidine (Oral Inhalation) and Dehydration

Generic Name: pentamidine
Dosage Forms: n.a.
Other Brand Names: Nebupent , Pentam 300 , Pentam

Result of checking the interaction of drug Pentamidine (Oral Inhalation) and disease Dehydration for safety when used together.

Check result:

Pentamidine (Oral Inhalation) <> Dehydration

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Patients who are dehydrated may be particularly susceptible to the nephrotoxic and hypotensive effects associated with the parenteral use of pentamidine. Dehydration should preferably be corrected prior to initiation of therapy. In patients who may be at risk for dehydration, such as those with severe and/or prolonged diarrhea or vomiting, fluid status and blood pressure should be monitored closely. If signs of renal irritation develop during therapy, hydration should be increased as indicated, accompanied by a reduction in dosage if necessary. Therapy should be withdrawn if urinary output decreases progressively or azotemia increases.

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