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Pepto-Bismol (Bismuth Subsalicylate Tablets) and Coagulation

Result of checking the interaction of drug Pepto-Bismol (Bismuth Subsalicylate Tablets) and disease Coagulation for safety when used together.

Check result:

Pepto-Bismol (Bismuth Subsalicylate Tablets) <> Coagulation

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

All salicylates can interfere with the action of vitamin K and induce a dose-dependent alteration in hepatic synthesis of coagulation factors VII, IX and X. At usual recommended dosages, a slight increase in prothrombin time (PT) may occur. Therapy with salicylates, especially if given in high dosages, should be administered cautiously in patients with significant active bleeding or a hemorrhagic diathesis, including hemostatic and/or coagulation defects associated with hemophilia, vitamin K deficiency, hypoprothombinemia, thrombocytopenia, thrombocytopathy, or severe hepatic impairment. The same precaution should also be observed with the use of related agents such as salicylamide because of their structural and pharmacological similarities to salicylate.

References:

Fausa O "Salicylate-induced hypoprothrombinemia: a report of four cases." Acta Med Scand 188 (1970): 403-8
"Product Information. Pepto-Bismol (bismuth subsalicylate)." Procter and Gamble Pharmaceuticals, Cincinnati, OH.
American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
"Product Information. Salflex (salsalate)." Carnrick Laboratories Inc, Cedar Knolls, NJ.
Barrow MV, Quick DT, Cunningham RW "Salicylate hypoprothrombinemia in rheumatoid arthritis with liver disease. Report of two cases." Arch Intern Med 120 (1967): 620-4

Pepto-Bismol (Bismuth Subsalicylate Tablets)

Generic Name: bismuth subsalicylate

Brand Name: Bismarex, Bismatrol, Bismatrol Maximum Strength, Kaopectate, Kola-Pectin DS, Maalox Total Stomach Relief, Peptic Relief, Pepto-Bismol, Pink Bismuth, Pepto-Bismol Maximum Strength, Maximum Strength Stress, Stress Maximum Strength, Kaopectate Extra Strength, Childrens Kaopectate, Kapectolin, Kao-Tin Bismuth Subsalicylate Formula, Kaopectate Anti-Diarrheal Upset Stomach Reliever, K-Pek, Soothe Chewable, Soothe Regular Strength, Soothe Maximum Strength, Soothe Caplets, Percy Medicine, Pepto-Bismol InstaCool

Synonyms: Pepto-Bismol

What is Pepto-Bismol (Bismuth Subsalicylate Tablets)?