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Polymyxin B and Neurotoxicity

Result of checking the interaction of drug Polymyxin B and disease Neurotoxicity for safety when used together.

Check result:

Polymyxin B <> Neurotoxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Parenteral use of polymyxin antibiotics may be associated with dose-related neurotoxic effects such as dizziness, drowsiness, confusion, irritability, nystagmus, muscle weakness, circumoral paresthesia, numbness of the extremities, slurred speech, ataxia, coma, and seizures. In addition, respiratory paralysis may occur as a result of neuromuscular blockade, particularly in patients with neuromuscular disease (e.g., myasthenia gravis, parkinsonian syndrome, botulism) or hypocalcemia and in patients receiving general anesthetics or neuromuscular blocking agents. Therapy with polymyxin antibiotics should be administered cautiously in patients at risk for neurotoxicity. The normally recommended dosages should not be exceeded in such patients, and renal function and serum drug concentrations should be monitored frequently during therapy to avoid excessive drug accumulation.

References:

"Product Information. Coly-Mycin M Parenteral (colistimethate)." Parke-Davis, Morris Plains, NJ.
"Product Information. Aerosporin (polymyxin B sulfate)." Glaxo Wellcome, Research Triangle Pk, NC.
"Multum Information Services, Inc. Expert Review Panel"

Polymyxin B

Generic Name: polymyxin b

Brand Name: Poly-Rx

Synonyms: n.a.

What is Polymyxin B?