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Preparation H (Phenylephrine Rectal Cream, Gel, and Ointment) and Cardiovascular

Result of checking the interaction of drug Preparation H (Phenylephrine Rectal Cream, Gel, and Ointment) and disease Cardiovascular for safety when used together.

Check result:

Preparation H (Phenylephrine Rectal Cream, Gel, and Ointment) <> Cardiovascular

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Topically applied sympathomimetic agents are systemically absorbed, with the potential for producing clinically significant systemic effects, particularly during prolonged or indiscriminate use. In cardiac tissues, these agents may produce positive chronotropic and inotropic effects via stimulation of beta-1 adrenergic receptors. Cardiac output, oxygen consumption, and the work of the heart may be increased. In the peripheral vasculature, vasoconstriction may occur via stimulation of alpha-1 adrenergic receptors. The use of topical sympathomimetic agents has rarely been associated with palpitations, tachycardia, arrhythmia, hypertension, reflex bradycardia, and coronary occlusion. Therapy with topical sympathomimetic agents should be administered cautiously in patients with sensitivity to sympathomimetic amines, hyperthyroidism, or underlying cardiovascular or cerebrovascular disorders, especially coronary insufficiency, cardiac arrhythmia, or hypertension.

References:

"Product Information. Neo-Synephrine Nasal (phenylephrine nasal)" Southwood Pharmaceuticals Inc, Irvine, CA.
Lansche RK "Systemic reactions to topical epinephrine and phenylephrine." Am J Ophthalmol 61 (1966): 95-8
Ellis PP "Systemic reactions to topical therapy." Int Ophthalmol Clin 11 (1971): 1-11
"Product Information. Neo-Synephrine (phenylephrine ophthalmic)" Sanofi Winthrop Pharmaceuticals, New York, NY.

Preparation H (Phenylephrine Rectal Cream, Gel, and Ointment)

Generic Name: phenylephrine topical

Brand Name: Anu-Med, Formulation R, Hemorid, Hemorrhoidal, Hemorrhoidal Cooling Gel, Medicone Hemorrhoidal, Preparation H Cooling Gel, Preparation H Suppositories, Prep-Hem, Preparation H, Hemorrhoidal Ointment, Anusert Ointment, Prompt Relief, Good Sense Hemorrhoidal, Avedana Hemorrhoidal

Synonyms: Phenylephrine (rectal), Phenylephrine (Topical)

What is Preparation H (Phenylephrine Rectal Cream, Gel, and Ointment)?