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Pyrazinamide and Liver disease

Result of checking the interaction of drug Pyrazinamide and disease Liver disease for safety when used together.

Check result:

Pyrazinamide <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Pyrazinamide is primarily metabolized by the liver. Patients with liver disease may be at greater risk for adverse effects from pyrazinamide due to decreased drug clearance. Dosage reductions are recommended in these patients if the drug is used.

References:

"Product Information. Pyrazinamide (pyrazinamide)." VersaPharm Inc, Marietta, GA.
Ellard GA "Absorption, metabolism and excretion of pyrazinamide in man." Tubercle 50 (1969): 144-58
Lacroix C, Tranvouez JL, Hoang T, Duwoos H, LaFont O "Pharmacokinetics of pyrazinamide and its metabolites in patients with hepatic cirrhotic insufficiency." Arzneimittelforschung 40 (1990): 76-9

Pyrazinamide

Generic Name: pyrazinamide

Brand Name:

Synonyms: n.a.

What is Pyrazinamide?