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Terbinafine (Systemic) and Renal dysfunction

Result of checking the interaction of drug Terbinafine (Systemic) and disease Renal dysfunction for safety when used together.

Check result:

Terbinafine (Systemic) <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of oral terbinafine in patients with renal impairment (CrCl <= 50 mL/min) has not been adequately studied and is, therefore, not recommended. Terbinafine metabolites are primarily eliminated by the kidney. The clinical significance of possible metabolite accumulation due to decreased clearance is unknown.

References:

Jensen JC "Clinical pharmacokinetics of terbinafine (Lamisil)." Clin Exp Dermatol 14 (1989): 110-3
"Product Information. Lamisil (terbinafine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.

Terbinafine (Systemic)

Generic Name: terbinafine

Brand Name: Lamisil, Terbinex

Synonyms: Terbinafine

What is Terbinafine (Systemic)?