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Thioguanine Tabloid and Liver disease

Result of checking the interaction of drug Thioguanine Tabloid and disease Liver disease for safety when used together.

Check result:

Thioguanine Tabloid <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hepatotoxicity usually presented as hepatic veno-occlusive disease (hyperbilirubinemia, tender hepatomegaly, weight gain due to fluid retention, and ascites) or with signs of portal hypertension (splenomegaly, thrombocytopenia, and esophageal varices), has been reported during therapy with thioguanine. Therapy with thioguanine should be administered cautiously in patients with liver disease or predisposed to it. Patients should be instructed to immediately report any signs of hepatotoxicity such as jaundice, dark urine, upper right quadrant pain, or anorexia. Clinical monitoring of hepatic function and determination of the etiology of hepatic dysfunction is recommended.

References:

Kao NL, Rosenblate HJ "6-Thioguanine therapy for psoriasis causing toxic hepatic venoocclusive disease." J Am Acad Dermatol 28 (1993): 1017-8
Gill RA, Onstad GR, Cardamone JM, Maneval DC, Sumner HW "Hepatic veno-occlusive disease caused by 6-thioguanine." Ann Intern Med 96 (1982): 58-60
"Product Information. Tabloid (thioguanine)." Prasco Laboratories, Cincinnati, OH.
Griner PF, Elbadawi A, Packman CH "Veno-occlusive disease of the liver after chemotherapy of acute leukemia. Report of two cases." Ann Intern Med 85 (1976): 578-82
Larrey D, Freneaux E, Berson A, Babany G, Degott C, Valla D, Pessayre D, Benhamou JP "Peliosis hepatis induced by 6-thioguanine administration." Gut 29 (1988): 1265-9
Satti MB, Weinbren K, Gordon-Smith EC "6-thioguanine as a cause of toxic veno-occlusive disease of the liver." J Clin Pathol 35 (1982): 1086-91

Thioguanine Tabloid

Generic Name: thioguanine

Brand Name: Tabloid

Synonyms: Thioguanine

What is Thioguanine Tabloid?