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Thiotepa and Hepatic dysfunction

Generic Name: thiotepa
Dosage Forms: n.a.
Other Brand Names: Thioplex , Tepadina

Result of checking the interaction of drug Thiotepa and disease Hepatic dysfunction for safety when used together.

Check result:

Thiotepa <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Thiotepa is rapidly metabolized by the liver to a biologically active form. The pharmacokinetic disposition of thiotepa has not be evaluated in patients with hepatic dysfunction. The use of thiotepa may be contraindicated in patients with existing hepatic damage. If the need outweighs the risk, extreme caution should be exercised in administering thiotepa and therapy should be initiated at a reduced dosage. Clinical monitoring of hepatic function is recommended.

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