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Tiglutik and Liver disease

Generic Name: riluzole
Dosage Forms: oral suspension
Other Brand Names: Rilutek , Tiglutik

Result of checking the interaction of drug Tiglutik and disease Liver disease for safety when used together.

Check result:

Tiglutik <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of riluzole has been frequently associated with an increase in liver enzymes between 3 and 5 times the upper limit of normal (ULN). Therapy with riluzole should be administered cautiously in patients with a history of liver dysfunction. Baseline liver function tests (LFTs) should be obtained in all patients. Monitor patients for signs and symptoms of hepatic injury, every month for the first 3 months of treatment, and periodically thereafter. The use of riluzole is not recommended if patients develop hepatic transaminases levels greater than 5 times the ULN. Discontinue riluzole if there is evidence of liver dysfunction (e.g., elevated bilirubin). Patients with mild or moderate [Child-Pugh score A and B] hepatic impairment had increases in AUC compared to patients with normal hepatic function, and may be at increased risk of adverse reactions. The impact of severe hepatic impairment on riluzole exposure is unknown.

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