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Tiludronate and Renal dysfunction

Result of checking the interaction of drug Tiludronate and disease Renal dysfunction for safety when used together.

Check result:

Tiludronate <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tiludronate is primarily eliminated by the kidney. The plasma half-life of the drug is prolonged in patients with impaired renal function. Tiludronate is not recommended for use in patients with creatinine clearance less than 30 mL/min due to a lack of clinical experience in this setting. No dosage adjustment is necessary in patients with mild to moderate renal impairment (CrCl >= 30 mL/min).

References:

Sansom LN, Necciari J, Thiercelin JF "Human pharmacokinetics of tiludronate." Bone 17 (1995): s479-83
Schwietert HR, Peeters PA, Dingemanse J, Thiercelin JF, Necciari J, de Bruin H, Jonkman JH "Multiple dose pharmacokinetics of tiludronate in healthy volunteers." Eur J Clin Pharmacol 51 (1996): 175-81
"Product Information. Skelid (tilundronate)." Sanofi Winthrop Pharmaceuticals, New York, NY.

Tiludronate

Generic Name: tiludronate

Brand Name:

Synonyms: n.a.

What is Tiludronate?