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Tipiracil and trifluridine and Hepatic impairment

Result of checking the interaction of drug Tipiracil and trifluridine and disease Hepatic impairment for safety when used together.

Check result:

Tipiracil and trifluridine <> Hepatic impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

No adjustment to the starting dosage of products containing the combination ingredients, trifluridine and tipiracil is recommended for patients with mild hepatic impairment. No clinically important differences in the mean exposures of trifluridine and tipiracil were observed between patients with mild hepatic impairment to moderate hepatic impairment and patients with normal hepatic function. Caution is recommended when using these agents in patients with severe hepatic impairment as their pharmacokinetics have not been studied in these patients. Do not initiate in patients with baseline moderate or severe (total bilirubin >1.5 times ULN and any AST) hepatic impairment.

Tipiracil and trifluridine

Generic Name: tipiracil / trifluridine

Brand Name: Lonsurf

Synonyms: Trifluridine and Tipiracil

What is Tipiracil and trifluridine?