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Tolcapone and Renal dysfunction

Generic Name: tolcapone
Dosage Forms: n.a.
Other Brand Names: Tasmar

Result of checking the interaction of drug Tolcapone and disease Renal dysfunction for safety when used together.

Check result:

Tolcapone <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Approximately 60% of tolcapone is eliminated by the kidney and < 0.5% is excreted unchanged in the urine. Dosage modification is not indicated for patients with mild to moderate renal impairment. The pharmacokinetic disposition of tolcapone has not been determined in patients with severe renal impairment and tolcapone should be administered cautiously in these patients.

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