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Abbokinase and Liver disease

Result of checking the interaction of drug Abbokinase and disease Liver disease for safety when used together.

Check result:

Abbokinase <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Urokinase undergoes extensive clearance and degradation by the liver. The pharmacokinetic disposition of urokinase has not been fully determined, however it is expected that the half-life of urokinase would be prolonged in patients with hepatic impairment. Therapy with urokinase should be administered cautiously in patients with compromised hepatic function. Clinical monitoring of bleeding functions should be determined prior to initiation of therapy. Measures of fibrinolytic activity and/or coagulation functions during infusion do not correlate with efficacy or risk of bleeding.

References:

"Product Information. Abbokinase (urokinase)." Abbott Pharmaceutical, Abbott Park, IL.
Matsuo O, Kosugi T, Mihara H "Urokinase inactivation rate in the rabbit: effect of circulatory isolation of the liver, spleen and kidneys." Haemostasis 7 (1978): 367-72
"Product Information. Abbokinase Open Cath (urokinase)." Abbott Pharmaceutical, Abbott Park, IL.

Abbokinase

Generic Name: urokinase

Brand Name: Kinlytic, Abbokinase, Abbokinase Open-Cath

Synonyms: Abbokinase (Intravenous)

What is Abbokinase?