Drug search by name

Tosymra and Liver disease

Result of checking the interaction of drug Tosymra and disease Liver disease for safety when used together.

Check result:

Tosymra <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The manufacturer considers the use of sumatriptan to be contraindicated in patients with severe hepatic impairment. Sumatriptan is primarily metabolized by the liver. Following subcutaneous administration, the pharmacokinetics of sumatriptan were not significantly altered in patients with hepatic impairment compared to healthy controls. Following oral administration, however, the bioavailability was substantially increased compared to controls, presumably because the liver plays an important role in the presystemic clearance of orally administered sumatriptan. The maximum single oral dose should generally not exceed 50 mg in patients with impaired hepatic function. Data are not available for the nasal formulation.

References:

"Product Information. Imitrex (sumatriptan)." Glaxo Wellcome, Research Triangle Park, NC.
Dixon CM, Saynor DA, Andrew PD, Oxford J, Bradbury A, Tarbit MH "Disposition of sumatriptan in laboratory animals and humans." Drug Metab Dispos 21 (1993): 761-9
Fowler PA, Lacey LF, Thomas M, Keene ON, Tanner RJ, Baber NS "The clinical pharmacology, pharmacokinetics and metabolism of sumatriptan." Eur Neurol 31 (1991): 291-4
"Product Information. Imitrex injection (sumatriptan)." Cerenex Pharmaceuticals, Research Triangle Pk, NC.

Tosymra

Generic Name: sumatriptan

Brand Name: Imitrex, Tosymra, Alsuma, Imitrex STATdose, Imitrex Statdose Refill, Sumavel DosePro, Zembrace SymTouch, SUMAtriptan Succinate Syringe, ONZETRA Xsail, Imitrex<, Zecuity

Synonyms: n.a.

What is Tosymra?