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Tramadol Extended-Release Capsules and Tablets and Liver disease

Generic Name: tramadol
Dosage Forms: n.a.
Other Brand Names: ConZip , Ultram , Ultram ER , Rybix ODT , Ryzolt

Result of checking the interaction of drug Tramadol Extended-Release Capsules and Tablets and disease Liver disease for safety when used together.

Check result:

Tramadol Extended-Release Capsules and Tablets <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tramadol is converted by the liver to several metabolites, one of which (referred to as M1) is pharmacologically active and a more potent analgesic than tramadol itself. The metabolism of both tramadol and M1 has been shown to decrease in patients with advanced cirrhosis of the liver, resulting in increased exposure to tramadol as well as substantially prolonged elimination half-lives for both tramadol and M1. Therapy with tramadol should be administered cautiously in patients with impaired hepatic function. The recommended dosage for patients with cirrhosis is 50 mg every 12 hours.

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