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Trifluridine and Tipiracil Hydrochloride and Renal dysfunction

Result of checking the interaction of drug Trifluridine and Tipiracil Hydrochloride and disease Renal dysfunction for safety when used together.

Check result:

Trifluridine and Tipiracil Hydrochloride <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

No adjustment to the starting dosage of products containing the combination ingredients, trifluridine and tipiracil is recommended for patients with mild or moderate renal impairment. The estimated mean AUC of trifluridine at steady state was 31% higher in patients with mild renal impairment and 43% higher in patients with moderate renal impairment than that in patient with normal renal function. The estimated mean AUC of tipiracil was 34% higher in patients with mild renal impairment and 65% higher in patients with moderate renal impairment than that in patients with normal renal function. Caution is recommended when using these agents in patient with severe renal impairment or end-stage renal disease as their pharmacokinetics have not been studied in these patients.

Trifluridine and Tipiracil Hydrochloride

Generic Name: tipiracil / trifluridine

Brand Name: Lonsurf

Synonyms: Tipiracil and trifluridine, Trifluridine and Tipiracil

What is Trifluridine and Tipiracil Hydrochloride?