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Trovan and Liver disease

Result of checking the interaction of drug Trovan and disease Liver disease for safety when used together.

Check result:

Trovan <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Trovafloxacin undergoes metabolism by the liver as well as excretion by the hepatobiliary system. Patients with hepatic impairment or biliary obstruction may be at greater risk for adverse effects from trovafloxacin due to decreased drug clearance. Therapy with trovafloxacin should be administered cautiously in these patients. The manufacturer recommends a dosage reduction in mild to moderate cirrhosis. Periodic assessment of hepatic function is advised, especially during prolonged therapy (>= 21 days), since trovafloxacin can also cause elevations of liver enzymes.

References:

Teng R, Harris SC, Nix DE, Schentag JJ, Foulds G, Liston TE "Pharmacokinetics and safety of trovafloxacin (CP-99,219), a new quinolone antibiotic, following administration of single oral dose to healthy male volunteers." J Antimicrob Chemother 36 (1995): 385-94
Dalvie DK, Khosla N, Vincent J "Excretion and metabolism of trovafloxacin in humans." Drug Metab Dispos 25 (1997): 423-7
"Product Information. Trovan (trovafloxacin)." Pfizer US Pharmaceuticals, New York, NY.
Teng R, Liston TE, Harris SC "Multiple-dose pharmacokinetics and safety of trovafloxacin in healthy volunteers." J Antimicrob Chemother 37 (1996): 955-63
Vincent J, Venitz J, Teng R, Baris BA, Willavize SA, Polzer RJ, Friedman HL "Pharmacokinetics and safety of trovafloxacin in healthy male volunteers following administration of single intravenous doses o the prodrug, alatrofloxacin." J Antimicrob Chemother 39 Suppl B (1997): 75-80
Haria M, Lamb HM "Trovafloxacin." Drugs 54 (1997): 435-45;disc. 446

Trovan

Generic Name: trovafloxacin

Brand Name:

Synonyms: n.a.

What is Trovan?