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Valacyclovir and Renal impairment

Result of checking the interaction of drug Valacyclovir and disease Renal impairment for safety when used together.

Check result:

Valacyclovir <> Renal impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Valacyclovir is almost completely converted in vivo to acyclovir, which is primarily eliminated by the kidney. Patients with renal impairment may be at greater risk for neuro- and nephrotoxicity (including further deterioration in renal function, tubular damage and acute renal failure) from acyclovir due to decreased drug clearance. Therapy with valacyclovir should be administered cautiously in patients with renal impairment. Dosage adjustments are recommended in patients with moderate to severe renal dysfunction.

References:

"Product Information. Valtrex (valacyclovir)." Glaxo Wellcome, Research Triangle Park, NC.
Laskin OL, Longstreth JA, Whelton A, et al "Acyclovir kinetics in end-stage renal disease." Clin Pharmacol Ther 31 (1982): 594-600
Laskin OL, Longstreth JA, Whelton A, et al "Effect of renal failure on the pharmacokinetics of acyclovir." Am J Med 73 (1982): 197-201

Valacyclovir

Generic Name: valacyclovir

Brand Name: Valtrex

Synonyms: ValACYclovir

What is Valacyclovir?