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Vioform Topical and Oculo-/neurotoxicity

Generic Name: clioquinol topical
Dosage Forms: n.a.
Other Brand Names:

Result of checking the interaction of drug Vioform Topical and disease Oculo-/neurotoxicity for safety when used together.

Check result:

Vioform Topical <> Oculo-/neurotoxicity

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of oral clioquinol (no longer marketed in the U.S.), generally at high dosages for prolonged periods, has resulted in ocular and neurologic toxicity, including optic neuritis, optic atrophy, and subacute myelo-optic neuropathy. Because the drug is systemically absorbed following topical administration to the skin, therapy with topical clioquinol should be administered cautiously in patients with peripheral neuropathy, optic neuritis, or preexisting visual defects. The use of occlusive dressings may substantially increase percutaneous absorption and should be avoided. All patients should be advised to immediately discontinue the drug and contact a physician if visual disturbances occur or are exacerbated during therapy. Clioquinol is not recommended for use in children and is contraindicated for those under 2 years of age.

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